What is Vasculitis?

If untreated, the vast majority of patients can die within a year. Current treatments improve prognosis, but affected patients remain at a substantially higher risk of death and adverse outcomes.

Since the discovery of anti-neutrophil cytoplasmic antibodies (ANCA) in 1982, enormous progress has been made in the understanding of the associated diseases and their treatment. From a diagnostic viewpoint, the elucidation of proteinase 3 (PR3) and myeloperoxidase (MPO) as the relevant antigenic specificities of ANCA in the ANCA-associated vasculitis (AAV) has strongly improved early diagnosis and treatment of these diseases.

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Treatment of AAV follows type- and activity-adapted regimens according to evidence from controlled trials which have been summarized in the EULAR (European League against Rheumatism) recommendations published in 2009.

In general, a period of remission induction using highly-potent immunosuppression (e.g. with cyclophosphamide, Cyc plus glucocorticoids, GC) for 3–4 months is followed by maintenance therapy (e.g. azathioprine plus low-dose GC) which is supposed to be kept for at least 1.5–2 years. Induction therapy with a combination of high-dose steroids and cyclophosphamide has been the standard therapy for over 30 years and greatly improves survival among patients with AAV. Current research is focused on improving efficacy and reducing side effects of the medications used to induce remission.

For EGPA, the current approach to disease management is primarily based on reduction of active inflammation and suppression of the immune response through the use of corticosteroids and concomitant immunosuppressive therapy (e.g., methotrexate, azathioprine, mycophenolate mofetil) and/or cytotoxic agents (e.g. cyclophosphamide). Although the use of these treatments can be effective for establishing remission, patients remain vulnerable to either the complications of the long-term use of these therapies and to the risk of relapse, particularly if the dose of corticosteroid is reduced.

Smart Job Scheduling Software for Tradies

A tradies job is hard enough as it is, so why not make things a little easier by using a Job Scheduling Software Solution designed for tradies? This software can help you manage the scheduling and dispatching process and send jobs directly to tradies on the ground. Tradies can then receive the assigned jobs on their mobile phones through the app and make any adjustments and amendments from the job site.

What is Job Scheduling Software?

Job Scheduling Software assists businesses to schedule their team across different job sites and tasks. Some scheduling software is built particularly for field service firms, where teams operate in the field and must travel to several appointments or task locations.

Benefits of Job Scheduling Software:

Multiple calendar views allow you to see all of your upcoming jobs at a glance

The user-friendly calendar view makes it simple to see a comprehensive list of all jobs assigned to your technicians. Switch between day, week, and month views in an instant, and drag and drop planned appointments to rearrange the day or time. With all your jobs tracked in the calendar, you get an instant snapshot of all your resources– field technicians, contractors and even equipment. You also have the option to filter for users, assets etc to see what has been scheduled.

Map View

To make scheduling your workforce easier, view all of your jobs on a map. Every time, send the right person to the right location. All of your favourite Google Maps features, including street view, are available to you. Real-time location processing allows your admin staff to schedule jobs to the closest available tradie.

Less travel time and more billable hours

With a geo-fence management solution, you can prevent your field workers from wasting time travelling long distances between jobs. You can define regions in the Job Scheduling Software and assign them to each technician. After that, you can easily assign a tradie to a job within that region.

Send Notifications Instantly

When you change an employee’s current workday schedule, they’ll receive a notification on their phone with all the details. Your field workers will be notified of their upcoming appointments via the Job Scheduling App. Your technicians can use the Mobile App to view all job details, leave comments as needed, get customer sign-off on completed work, and schedule any follow-up work orders.

Collect customer signatures when work is completed

You can easily collect customer signatures on your mobile device with Job Scheduling Software. The customer’s signature is then added to the completed job and stored in the system as proof of completion. Completed work orders can be sent to the client with their invoice for payment directly after a job is completed.

Analyse and share reports

Examine each report in detail to determine which tasks were completed on-site and by whom, how much time was spent travelling versus working, and whether you need to schedule a follow-up appointment for additional work. You can even use a live web view to share the report with your customers, complete with your company logo and contact information.

Beware of Cyberattack, It may destroy your company/personal confidential data

Cyber Attacks are the ongoing buzz all around the World. Before knowing the Cyber attacks let us understand what is Cyber Attacks? what are the tricks or techniques, hackers are using to expose, steal, alter, destroy or gain unauthorized access to an asset? What are Cyber Attacks? Cyber attacks are the type of offensive maneuver that targets computer information systems, infrastructures, computer networks, or personal computer devices. Cyberattacks Can be named as a cyber campaign, cyber-warfare, or Cyber Terrorism. Types of Cyber Attacks are as mentioned below:-
Active Attacks attempt to change system resources or affect their operation.
Passive Attacks attempts to learn or make use of information from the system but does not affect system resource.
Inside Attack is an attack initiated by an entity that is authorized to access system resources but used them in the wrong way.
An outside Attack is an attack initiated outside the perimeter, by the illegitimate user of the system. Outside hackers range from amateur pranksters to organized criminals, hostile governments, International criminals.
Types of Cyber Attacks:-
Malware (malicious software) is downloaded to a targeted computer that can do anything from steal data to encrypt files and demand ransoms.
Phishing emails are crafted to fool victims’ emails into giving up passwords or taking some other harmful action.
Denial of Service Attacks, which overwhelm a web server with bogus traffic.
Man in the middle attacks fools the target computer into joining a comprised network.
The Biggest Cyber Attacks
WannaCry
NotPetya
Ethereum
Equinox
Yahoo( All 3 Billion yahoo email addresses affected)
GitHub(Massive denial of service attack) and many more.
Cyber Attack Prevention Tips:-
The Government and the organizations can work together to fight cyber attacks.
Point-of-sale terminals are a vector for malware and data theft. Point-of-sale terminals include marketing/Sales cooperatives, retailers, hotels, restaurants which are victimized through the same heel that Cybercriminals continue to attack: Point-of-Sale system where Customer payment details, Sales Employee Travel claim details are routinely processed.
However, Security experts are encouraging a variety of approaches to keep businesses secure from point-of-sales intrusion. Here are a few to know and consider monitoring, Encryption, Testing each and every time when you connect with point-of-sale terminals. If you want to access remote sales employee information like travel expense details, customer payments bills & other work-related billing attachments online with safety you can opt for Travelize Application. TRAVELIZE is a trusted & encrypted-Employee GPS location & Monitoring Software that is mainly designed to serve all types of organizations. Travelize strives for Encapsulation, Data Security, Data integrity & Encryption.

Mexico Striving to Preserve the Past, Present and Future

“Don’t take tourism for granted” says Mexico’s Secretary of Tourism Gloria Guevara Manzo in recent published remarks as the nation looks at preserving its’ past, present and future while generating jobs, wealth and well being for its’ citizens.

Last year was a milestone year for travel and tourism in Mexico as the country’s industry contributed 100 million jobs and over $2 trillion in GDP.

The people of Mexico realize that travel and tourism are powerful engines for driving positive socio-economic change and as such, tourism is a national priority.

In 2011 there were a record-setting 22.67 million international visitors who came to Mexico, the most since records started being kept in 1980 by the Bank of Mexico.

The goal is to take Mexico from the 10th tourism destination to the Top 5 by 2018.

Mexico is promoting sustainability and is a global leader in the fight against climate change – promoting “green growth” development and attractions.

Throughout the country there is an effort to organize attractions and to effectively target market them to the world.

Diversification of these markets, products and destinations has helped Mexico over the years to be a more popular destination with the majority of its tourism coming from America.

Tourism is now Mexico’s third largest industry and it set to grow steadily over the coming years.

A key attraction is a lasting legacy for travelers – those who come to Mexico can see, touch and be moved by centuries of history, from 500-700 A.D., to the present. This rich history is very unique as it reaches back to before the Spanish arrival in 1519 when Indians roamed the land.

Early cultures included the Maya, Totonac, Huastec, Otomi, Mixtecs, Zapotecs, Tlaxcalans, Tarascans and Aztecs. And all these cultures created a vast number of historical wonders which visitors can tour first hand.

The lasting influence of the Spanish arrival in 1519 left a lasting influence through the entire fabric of the country. Now tourists from over 140 countries enjoy that legacy for the New World conquerors. Mexico displays her Colonial legacy in most all of her states and particularly in the capital.

Sites listed by a recent tourism promotion note that in Central Mexico “it is possible to enjoy the Churches of Guadalupe, San Marcos, San Diego and The Government Palace in Aguascalientes. In Cuernavaca, cradle of the Revolutionary War led gy Emiliano Zapata, stand the Cathedral (XVI century) and the Palacio de Cortes (constructed in 1538).

Visitors to Guanajuato will find a great examples of Colonial heritage and in the city of Puebla are the many churches.